DNAmGrimAge

1. DNAmGrimAge mediates mortality in humans (approximately 50%).

   “DNAmGrimAge accounted for the largest proportion, approximately 50%, of the educational inequalities for men, while the proportion was negligible for women.”

   Humanseducational inequalities in mortalitybloodmalesn = 13,021

   The Role of Epigenetic Clocks in Explaining Educational Inequalities in Mortality: A Multicohort Study and Meta-analysis

   The journals of gerontology. Series A, Biological sciences and medical sciences·Feb 17, 2022

1. Suicide attempt increases DNAmGrimAge in humans (+7.3 years (mean 24.6% increase)).

   “Baseline DNAmGrimAge exceeded chronological age by 7.3 years on average across all samples, conferring a mean 24.6% increase in relation to actual age.”

   Humanswhole bloodn = 88

   Accelerated epigenetic aging in suicide attempters uninfluenced by high intent-to-die and choice of lethal methods

   Translational psychiatry·Jun 2, 2022

1. DNAmGrimAge predicts Alzheimer's disease in humans.

   “DNAmPhenoAge and DNAmGrimAge, predicted progression from cognitively normal aging to mild cognitive impairment or AD”

   Humans

   DNA methylation age from peripheral blood predicts progression to Alzheimer's disease, white matter disease burden, and cortical atrophy

   Research square·Oct 28, 2024Preprint

More on Alzheimer's disease

1. DNAmGrimAge is associated with telomere length in humans.

   “DNAmGrimAge and DNAmPhenoAge acceleration were inversely associated with telomere length assessed by both methods.”

   Humans

   No strong association among epigenetic modifications by DNA methylation, telomere length, and physical fitness in biological aging

   Biogerontology·Jan 2, 2023

More on Telomere length

1. DNAmGrimAge predicts cardiovascular events in humans.

   “Interestingly, the performance of DNAmGrimAge and DNAmCVDscore was comparable (slightly lower for DNAmGrimAge, although the differences were not statistically significant).”

   Humansshort-term CVD risk

   A blood DNA methylation biomarker for predicting short-term risk of cardiovascular events

   Research Square·Jun 2, 2022Preprint

More on Cardiovascular events

1. Depressive symptoms are associated with DNAmGrimAge in humans (corrected p's < 0.05).

   “depressive symptomatology and more neuropathic pain symptoms were significantly associated with an older epigenome in only one of the five epigenetic clocks (i.e. DNAmGrimAge)”

   Humansbloodn = 213

   Epigenetic age predictors in community-dwelling adults with high impact knee pain

   Molecular pain·Apr 1, 2022

More on Depressive symptoms

1. Knee pain is associated with DNAmGrimAge in humans.

   “Only DNAmPhenoAge and DNAmGrimAge were associated with higher knee pain intensity during the past 48 h.”

   Humansbloodn = 213

   Epigenetic age predictors in community-dwelling adults with high impact knee pain

   Molecular pain·Apr 1, 2022

1. High-impact chronic pain is associated with DNAmGrimAge in humans.

   “pain-related disability during the past 6 months was associated with markers of epigenetic aging.”

   Humansbloodn = 213

   Epigenetic age predictors in community-dwelling adults with high impact knee pain

   Molecular pain·Apr 1, 2022

More on High-impact chronic pain