High-impact chronic pain

1. High-impact chronic pain increases pain intensity in humans (median: 6 [4, 8] vs 5 [3, 6], P<0.0001).

   “average pain intensity (median: 6 [4, 8] vs 5 [3, 6], P<0.0001)”

   Humansn = 508

   Concurrent Validity of the Operationalization of High-Impact Pain Construct in the Health and Retirement Study

   Journal of pain research·22 Oct 2025

1. High-impact chronic pain increases pain-related disability in humans (median PDI: 48 [33, 60] vs 19 [8, 36], P<0.0001).

   “Those with high-impact pain had significantly higher pain-related disability (median PDI: 48 [33, 60] vs 19 [8, 36], P<0.0001)”

   Humansn = 508

   Concurrent Validity of the Operationalization of High-Impact Pain Construct in the Health and Retirement Study

   Journal of pain research·22 Oct 2025

1. High-impact chronic pain is associated with chronic pain in humans (OR 1.75 (95% CI: 1.19, 2.58)).

   “were more likely to report chronic (OR: 1.75 [95% CI: 1.19, 2.58]) and constant (OR: 3.09 [1.93, 4.93]) pain”

   Humansn = 508

   Concurrent Validity of the Operationalization of High-Impact Pain Construct in the Health and Retirement Study

   Journal of pain research·22 Oct 2025

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