For low calcium, adjusted hazard ratios—measures of relative event rates—rose from 1.27 with one abnormal reading to 1.84 with at least three.For low calcium, adjusted hazard ratios—measures of relative event rates—rose from 1.27 with one abnormal reading to 1.84 with at least three.
In 3,194 people with heart failure, links between protein-based aging measures and outcomes varied with diabetes, high blood pressure and symptom severity.In 3,194 people with heart failure, links between protein-based aging measures and outcomes varied with diabetes, high blood pressure and symptom severity.
Calorie restriction producing 20% weight loss reduced time spent in an irregular heart rhythm to 22.7 seconds, versus 227 seconds in obese mice without weight loss.Calorie restriction producing 20% weight loss reduced time spent in an irregular heart rhythm to 22.7 seconds, versus 227 seconds in obese mice without weight loss.
The pressure-related component was linked to 19% higher relative stroke risk per standard deviation, a measure of how much readings varied between participants.The pressure-related component was linked to 19% higher relative stroke risk per standard deviation, a measure of how much readings varied between participants.
Sleep scores of one and two had adjusted hazard ratios of 0.907 and 1.117 versus zero, relative death-rate measures whose uncertainty ranges included no difference.Sleep scores of one and two had adjusted hazard ratios of 0.907 and 1.117 versus zero, relative death-rate measures whose uncertainty ranges included no difference.
Who was studied33,661 adults without diabetes and with elevated BMI
What changedCardiovascular death risk was higher with sleep problems and advanced heart-kidney-metabolic risk together than their separate effects would predict
The catchSleep impairment scores relied partly on self-reported sleep trouble, making them vulnerable to reporting errors
Compared with noncarriers, people with one copy had 2.09 times the odds of reduced heart-pumping function; those with two copies had 11.03 times the odds.Compared with noncarriers, people with one copy had 2.09 times the odds of reduced heart-pumping function; those with two copies had 11.03 times the odds.
In experiments in newborn mice, reducing SMURF2, an enzyme that tags proteins for breakdown, improved heart function and reduced scarring after heart injury.In experiments in newborn mice, reducing SMURF2, an enzyme that tags proteins for breakdown, improved heart function and reduced scarring after heart injury.
The model outperformed conventional methods, with one-year scores of 0.946 in TriNetX and 0.945 in eMERGE for distinguishing future cases from noncases.The model outperformed conventional methods, with one-year scores of 0.946 in TriNetX and 0.945 in eMERGE for distinguishing future cases from noncases.
A 19-protein score achieved 0.80 versus 0.76 for clinical risk factors alone on a measure of how well it distinguished future heart failure cases.A 19-protein score achieved 0.80 versus 0.76 for clinical risk factors alone on a measure of how well it distinguished future heart failure cases.
Each doubling of the blood protein osteopontin was linked to hazard ratios of 1.16 for atrial fibrillation and 1.30 for dementia.Each doubling of the blood protein osteopontin was linked to hazard ratios of 1.16 for atrial fibrillation and 1.30 for dementia.
At one year, users had a lower relative rate of major heart and blood vessel events than nonusers, with a hazard ratio of 0.40.At one year, users had a lower relative rate of major heart and blood vessel events than nonusers, with a hazard ratio of 0.40.
In Massachusetts General Hospital’s test group, 10-year prediction scores were 0.87 for heart failure with reduced ejection fraction and 0.79 for preserved ejection…In Massachusetts General Hospital’s test group, 10-year prediction scores were 0.87 for heart failure with reduced ejection fraction and 0.79 for preserved ejection fraction.
Scan features scored 0.83 versus 0.74 for a clinical risk score in distinguishing who developed the condition; 1 would mean perfect separation.Scan features scored 0.83 versus 0.74 for a clinical risk score in distinguishing who developed the condition; 1 would mean perfect separation.
Experiments compared mutant and control mice at 2 and 24 months, finding early changes in cells lining brain blood vessels.Experiments compared mutant and control mice at 2 and 24 months, finding early changes in cells lining brain blood vessels.
In validation data, a model using aortic shape scored 0.87 for risk ranking, compared with 0.82 for a model using diameter measurements.In validation data, a model using aortic shape scored 0.87 for risk ranking, compared with 0.82 for a model using diameter measurements.
The relative rate of death over five years was lower among Hispanic adults than matched non-Hispanic White adults, with a hazard ratio of 0.846.The relative rate of death over five years was lower among Hispanic adults than matched non-Hispanic White adults, with a hazard ratio of 0.846.
For 10-year heart failure prediction, a scan-based model scored 0.84 versus 0.72 for a clinical score in distinguishing future cases from people who remained unaffected.For 10-year heart failure prediction, a scan-based model scored 0.84 versus 0.72 for a clinical score in distinguishing future cases from people who remained unaffected.
Increasing the protein’s levels in mouse livers lowered blood cholesterol and liver fat, while removing it worsened cholesterol levels and fat buildup.Increasing the protein’s levels in mouse livers lowered blood cholesterol and liver fat, while removing it worsened cholesterol levels and fat buildup.
Mice with high cholesterol developed less artery plaque when researchers deleted an enzyme from blood-vessel lining cells in experiments on disturbed blood flow.Mice with high cholesterol developed less artery plaque when researchers deleted an enzyme from blood-vessel lining cells in experiments on disturbed blood flow.
A genetic analysis identified 112 DNA regions linked to both coronary artery disease and traits related to thinking or education.A genetic analysis identified 112 DNA regions linked to both coronary artery disease and traits related to thinking or education.
Genetically altered mice also had lower levels of aldosterone, a hormone involved in blood pressure control, than unmodified controls.Genetically altered mice also had lower levels of aldosterone, a hormone involved in blood pressure control, than unmodified controls.
Experiments in adult mice found that increasing a growth-supporting enzyme promoted heart muscle cell division and improved heart function after a heart attack.Experiments in adult mice found that increasing a growth-supporting enzyme promoted heart muscle cell division and improved heart function after a heart attack.
More than 1,200 blood proteins were linked to future heart failure about 18 years before diagnosis, rising to about 3,600 closer to diagnosis.More than 1,200 blood proteins were linked to future heart failure about 18 years before diagnosis, rising to about 3,600 closer to diagnosis.
Mice engineered to increase glucose breakdown in blood vessel–lining cells showed poorer blood-flow recovery and lower capillary density after hindlimb blood supply was…Mice engineered to increase glucose breakdown in blood vessel–lining cells showed poorer blood-flow recovery and lower capillary density after hindlimb blood supply was restricted.
