CLOCK
Biomarker1 paper
- Animals1
Latest
36Sorafenib reduced cognitive deficits in desflurane-exposed mice
In 18-month-old mice of both sexes exposed to 2% desflurane for two hours, sorafenib pretreatment restored CLOCK protein and improved cognitive…In 18-month-old mice of both sexes exposed to 2% desflurane for two hours, sorafenib pretreatment restored CLOCK protein and improved cognitive performance.
Disease mutations shift epigenetic age in organoids
In a preprint using iPSC-derived organoids, serial passaging re-established aging trajectories while disease-associated mutations drove additional…In a preprint using iPSC-derived organoids, serial passaging re-established aging trajectories while disease-associated mutations drove additional cell-intrinsic shifts in epigenetic age.
Direct conversion to neural stem cells de-ages human blood cells
Converted cells preserved around 13% and 5% of original donor age at low and high passages, respectively, through a protracted de-aging process.Converted cells preserved around 13% and 5% of original donor age at low and high passages, respectively, through a protracted de-aging process.
Somatic mutations track age in reef-building corals
Whole-genome sequencing of eight coral colonies showed somatic mutations followed power-law distributions, faced purifying selection, and helped age a…Whole-genome sequencing of eight coral colonies showed somatic mutations followed power-law distributions, faced purifying selection, and helped age a colony to nearly a century.
Early life stress accelerates epigenetic aging in zebra finches
Corticosterone treatment shifts DNA methylation profiles in young chicks toward those of older birds and reshapes longevity pathways.Corticosterone treatment shifts DNA methylation profiles in young chicks toward those of older birds and reshapes longevity pathways.
Proteomic organ clocks predict mortality but trail established physiological and epigenetic biomarkers
In an older Scottish cohort, epigenetic age and brain volume outmatched plasma proteomic organ clocks for predicting long-term all-cause mortality.In an older Scottish cohort, epigenetic age and brain volume outmatched plasma proteomic organ clocks for predicting long-term all-cause mortality.
Blood cell composition explains substantial variation in DNA methylation age
Cell counts explain less variation in age acceleration and only modestly affect its links to mortality and 176 incident health outcomes.Cell counts explain less variation in age acceleration and only modestly affect its links to mortality and 176 incident health outcomes.
Mechanistic biological age clock matches PhenoAge in predicting human mortality
The systems pharmacology model splits biological age into organ axes, revealing that pharmacological drops in inflammation may not translate to…The systems pharmacology model splits biological age into organ axes, revealing that pharmacological drops in inflammation may not translate to expected risk reductions.
Epigenetic puberty index tracks biological aging and adult health risks
A DNA-methylation measure of pubertal development correlates with established epigenetic clocks and predicts mortality and disease in two large adult…A DNA-methylation measure of pubertal development correlates with established epigenetic clocks and predicts mortality and disease in two large adult cohorts.