Chondroitin sulfate

3 papers1 finding

Humans1
Animals2

Upstream

1

Alzheimer's disease

downin humans1

1 study

Alzheimer's disease decreases chondroitin sulfate in humans.
“AD-LBD brainstem tissue exhibited significantly reduced unsulfated, 4-O-sulfated, and total CS levels”
HumansAD co-pathologyprefrontal cortex
Mass spectrometry analysis of young and aged mice and human Alzheimer's disease with Lewy body pathology using on-slide tissue digestion
Analytical and bioanalytical chemistry28 Feb 2026

More on Alzheimer's disease

Funding

3 grants since 2016

Japan Society for the Promotion of ScienceJP¥12.9m

Latest

6 in 12 months

Glia1 Oct

Oral 4-methylumbelliferone remodels brain extracellular matrix and improves memory in aged mice

The compound reduced perineuronal nets, dampened glial activation, and cut immune cell infiltration while restoring recognition memory.The compound reduced perineuronal nets, dampened glial activation, and cut immune cell infiltration while restoring recognition memory.

Experiments in miceInterventions

Biomolecules27 Aug

Chondroitin Sulfate Supplementation Is Associated with Body Weight Control in Ovariectomized Rats: A Multi-Omics Study of Gut Microbiota and Metabolite Profiles

Experiments in ratsGut and microbiome

Journal of the Science of Food and Agriculture14 Aug

2'-Fucosyllactose attenuates estrogen-deficiency-associated bone loss and intestinal dysfunction in ovariectomized rats

Experiments in ratsGut and microbiome

FASEB Journal19 Apr

CSPG4 Mediates Inflammatory, Cell Death, and Senescence Responses in Enteric Glia Exposed to Clostridioides difficile Toxins

Experiments in miceDNA damage response

Analytical and Bioanalytical Chemistry28 Feb

Mass spectrometry analysis of young and aged mice and human Alzheimer's disease with Lewy body pathology using on-slide tissue digestion

Cross-sectional study of 14 peopleAI & data

Materials Today Bio1 Dec

Spermidine-encapsulated chondroitin sulfate methacryloyl hydrogel delivery system for remodeling bone homeostasis in rheumatoid arthritis

Experiments in miceSpermidine

Journal of Nanobiotechnology12 Oct

Spontaneous hydrogen-releasing nanoenzyme alleviates osteoarthritis via oxidative stress reduction and mitochondrial dysfunction reversal

Experiments in animalsOsteoarthritis

ACS Nano2 May

Nicotinamide Adenine Dinucleotide-Loaded Lubricated Hydrogel Microspheres with a Three-Pronged Approach Alleviate Age-Related Osteoarthritis

Experiments in miceOsteoarthritis

bioRxiv14 Mar

Experimental Confirmation of Osteoarthritis Repair In Vivo Using Epigenetic Reprogramming with Small Chemical Molecules

Preprint: experiments in animalsInterventions

Aging Cell8 Oct

Increased levels of extracellular matrix proteins associated with extracellular vesicles from brains of aged mice

Experiments in animalsMechanisms