Ceramides
Biomarker1 paper1 finding
Effects
1Mitochondrial dysfunction
upin humans1
1 study
Mitochondrial dysfunction
upin humans1
Ceramides induce mitochondrial dysfunction in humans.
Reviewcardiomyocyte
Heart Failure: Lipid Metabolism Disorders Driving Cellular Senescence Through a Vicious Cycle, and Possible Intervention Strategies · Frontiers in bioscience (Landmark edition) · 1 Aug 2026
Latest
4CellsPreprint
Aged human muscle secretes an enzyme that impairs stem cell maintenance
Profiling conditioned media revealed that altered sphingolipid signaling reduces muscle stem cell pools in human cell cultures.
Suppressing neuronal dENL/AF9 shifts metabolic and energetic profiles in aged flies
Multi-omics profiling in Drosophila links chromatin regulation to increased ATP, higher NAD-to-NADH ratios, and altered lipid metabolism in aged heads.
Disrupted sphingolipid metabolism drives lysosomal and mitochondrial failure in Parkinson's disease
A preprint shows SMPD1 upregulation collapses a sphingolipid salvage pathway, causing mitophagy defects and marking aggressive motor phenotypes.