Higher blood levels of the protein cathepsin B were linked to lower lesion volume, with an association estimate of minus 0.09 in 5,260 people.Higher blood levels of the protein cathepsin B were linked to lower lesion volume, with an association estimate of minus 0.09 in 5,260 people.
Cohort study of 5,260 UK Biobank participantsMechanisms
Limit: The postmortem comparison supporting lesion-related cathepsin B changes involved only eight samples
A Parkinson’s-linked change in the CHCHD2 protein worsened nerve-fibre damage and problems with thinking.A Parkinson’s-linked change in the CHCHD2 protein worsened nerve-fibre damage and problems with thinking.
Experiments in aged transgenic mice and wild-type littermates, against WT and D2WT miceMechanisms
Limit: ~50% lower mutant protein abundance could contribute to differences between transgenic groups
In an animal experiment, mice whose ovaries had been removed showed worse osteoporosis and anxiety- and depression-like behaviour after eight weeks of chronic stress.In an animal experiment, mice whose ovaries had been removed showed worse osteoporosis and anxiety- and depression-like behaviour after eight weeks of chronic stress.