1 paper
An eight-week experiment in 22-month-old mice found comparable benefits in males and females given a ketogenic diet rather than standard chow.An eight-week experiment in 22-month-old mice found comparable benefits in males and females given a ketogenic diet rather than standard chow.
Long-lived African turquoise killifish show ventricular enlargement, fibrosis, and reduced myocardial density with age rather than typical cardiomyocyte hypertrophy.Long-lived African turquoise killifish show ventricular enlargement, fibrosis, and reduced myocardial density with age rather than typical cardiomyocyte hypertrophy.
The compound lowered senescence markers and improved heart function through SIRT3-driven DRP1 deacetylation in aged mice and cultured cardiomyocytes.The compound lowered senescence markers and improved heart function through SIRT3-driven DRP1 deacetylation in aged mice and cultured cardiomyocytes.
Mice lacking the receptor also showed higher inflammation, elevated DNA damage, and a five-month reduction in median lifespan.Mice lacking the receptor also showed higher inflammation, elevated DNA damage, and a five-month reduction in median lifespan.