Blood proteins

1. Blood proteins are associated with incident ischemic stroke in humans (Participants without prevalent stroke at proteomic profiling) (44 significant protein associations; 26 novel; P <1.0×10 −5).

   “44 proteins were significantly associated with ischemic stroke risk”

   HumansParticipants without prevalent stroke at proteomic profilingbloodn = 14,139

   Blood proteins linked to later stroke risk in two studies

   Stroke·Nov 12, 2026

More on Incident ischemic stroke

1. Blood proteins predict dementia in humans (UK Biobank prospective cohort).

   “MR analyses suggested that the associations between key metabolic and protein markers with dementia outcomes and brain volumes may be causal.”

   HumansUK Biobank prospective cohortblood

   Integrative Multi‐Omics Approaches to improve early Detection and Decipher Causal Pathways in Dementia

   AAIC 2025 abstract·Dec 23, 2025

More on Dementia

1. Blood proteins are associated with cardiometabolic disease in humans (prospective cohort) (pooled odds ratio ranged from 0.8-1.18).

   “The identified proteins were prospectively associated with cardiometabolic diseases (pooled odds ratio ranged from 0.8-1.18)”

   Humansprospective cohortn = 3,742

   Association of the EAT-Lancet diet, serial measures of serum proteome and gut microbiome, and cardiometabolic health: a prospective study of Chinese middle-aged and elderly adults

   The American journal of clinical nutrition·Dec 23, 2024

More on Cardiometabolic disease

1. Blood proteins are associated with heart failure in silico.

   “Nineteen blood proteins were causally associated with HF, were not subject to reverse causality and were enriched in ligand-receptor and glycosylation molecules.”

   In silico

   Mendelian randomization of circulating proteome identifies actionable targets in heart failure

   BMC genomics·Aug 13, 2022

More on Heart failure

1. Blood proteins are associated with Hannum extrinsic epigenetic age acceleration in ischemic stroke patients (P<0.05).

   “42 blood protein levels were associated with Hannum-extrinsic EAA (P<0.05), belonging to the immune effector process (P=1.54×10−6) and platelet degranulation (P<8.74×10−6) pathways.”

   Humansin ischemic stroke patients

   Biological Age Acceleration Is Lower in Women With Ischemic Stroke Compared to Men

   Stroke·Feb 25, 2022

More on Hannum extrinsic epigenetic age acceleration