What does the research say about incident ischemic stroke?

Incident ischemic stroke

There are 3 papers on incident ischemic stroke in aging research: 3 observational studies in people. The newest story, Nov 6, 2026: “Sickle cell trait showed no clear link to stroke in adults”.

Disease

3 papers study it37 more mention it7 findings

4 new papers in 30 daysSee all 40 papers on incident ischemic stroke

“chronic kidney disease (CKD) [2.2, (1.73, 2.81)]”

Non-cardiac and cardiac risk for ischemic stroke in young adults: The Stanford Y-CORE (Young Cardiovascular Outcomes and Risk Evaluation) studyInternational journal of stroke : official journal of the International Stroke Society2025doi:10.1177/17474930251338611

Humans3

Upstream

Sickle cell trait

no changein humans1HR 1.06

1 study

Sickle cell trait was not clearly linked with incident ischemic stroke in humans (HR 1.06, 95% CI 0.89-1.25; p = 0.53).
“After multivariable adjustment, SCT was not significantly associated with incident ischemic stroke”
HumansHeterozygous HbAS versus homozygous reference HbAA, after adjustment for genetic ancestry and vascular risk factorsMean follow-up, 12.25 yearsn = 275,530
Sickle cell trait showed no clear link to stroke in adults
Neurology. GeneticsNov 4, 2026

Associations

Sickle cell disease

upin humans1HR 5.12

1 study

Sickle cell disease is associated with incident ischemic stroke in humans (Homozygous variant HbSS versus homozygous reference HbAA) (HR 5.12, 95% CI 2.96-8.85; p < 0.001).
“In contrast, HbSS was associated with a markedly elevated hazard of ischemic stroke”
HumansHomozygous variant HbSS versus homozygous reference HbAAn = 144
Sickle cell trait showed no clear link to stroke in adults
Neurology. GeneticsNov 4, 2026

Latest

23 papers in 12 months

Neurology GeneticsNov 6

Sickle cell trait showed no clear link to stroke in adults

After adjustment, adults with the trait had a relative hazard of 1.06 for strokes from blocked blood flow compared with adults without the variant.After adjustment, adults with the trait had a relative hazard of 1.06 for strokes from blocked blood flow compared with adults without the variant.

Cohort · 275,530 peopleSickle cell disease

Paper

ESC Congress 2026 AbstractOct 26

Midlife blood pressure over time is linked to heart disease risk

Among untreated adults, each 10 millimeters of mercury higher average systolic pressure carried a hazard ratio of 1.19 for cardiovascular disease versus 1.08 for a single…Among untreated adults, each 10 millimeters of mercury higher average systolic pressure carried a hazard ratio of 1.19 for cardiovascular disease versus 1.08 for a single check.

Cohort · 92,729 peoplePopulations

Paper

International Journal of StrokeApr 19

Non-cardiac and cardiac risk for ischemic stroke in young adults: The Stanford Y-CORE (Young Cardiovascular Outcomes and Risk Evaluation) study

Cohort study of 540,999 peopleIschemic stroke

Paper

Frontiers in NutritionOct 29

Sulfur microbial diet and ischemic stroke risk

Cohort study of 208,415 peopleIschemic stroke

Paper

ESC Congress 2026 AbstractOct 26

Integrated stroke care and risk of recurrent stroke: Compliance with the ABCstroke pathway in Denmark

Cohort study of 42,996 peoplePopulations

Paper

NeuroepidemiologySep 30

Air pollution links to stroke risk in two population cohorts

In UK Biobank, every 5 µg/m³ increment in PM2.5 carried an incident ischemic stroke hazard ratio of 1.29, reaching 1.44 alongside high genetic susceptibility.In UK Biobank, every 5 µg/m³ increment in PM2.5 carried an incident ischemic stroke hazard ratio of 1.29, reaching 1.44 alongside high genetic susceptibility.

Cohort study of 368,644 peopleStroke

Paper

MaturitasSep 19