Graft failure

Disease2 papers1 finding

  • Humans2

Associations

1

Clonal hematopoiesis of indeterminate potential

upin humans1

1 study
  1. Clonal hematopoiesis of indeterminate potential is associated with graft failure in humans.

    “Additionally, the study showed that the re-emergence of recipient-derived clones, particularly oncogenic DNMT3A mutations, frequently preceded graft failure or disease relapse.”

    Humansre-emergence of recipient-derived clones, particularly oncogenic DNMT3A mutations, post-HSCTn = 20

    Donor TET2 variant links to shorter transplant survival · International journal of molecular sciences · 9 Sep 2026

Clonal hematopoiesis of indeterminate potential →

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International Journal of Molecular SciencesHumans

Donor TET2 variant links to shorter transplant survival

Recipients of stem cells from donors carrying the TET2 Leu1721Trp variant had a median survival of 14.3 months compared with 50.8 months for wild-type…Recipients of stem cells from donors carrying the TET2 Leu1721Trp variant had a median survival of 14.3 months compared with 50.8 months for wild-type donors.