What does the research say about ASXL1 CHIP?

ASXL1 CHIP

There is 1 paper on ASXL1 CHIP in aging research: 1 observational study in people. The newest story, Oct 26, 2026: “Blood mutations linked to heart, kidney, and metabolic disease”.

Biomarker

1 paper studies it7 more mention it

3 new papers in 30 daysSee all 8

Humans1

Latest

5 papers in 12 months

ESC Congress 2026 AbstractOct 26

Blood mutations linked to heart, kidney, and metabolic disease

Participants with age-related expansion of mutated blood cells had an adjusted hazard ratio of 1.11 for progression to syndrome stage 4 compared with participants without…Participants with age-related expansion of mutated blood cells had an adjusted hazard ratio of 1.11 for progression to syndrome stage 4 compared with participants without the condition.

Cohort · 433,924 peopleStage 4 cardiovascular-kidney-metabolic syndrome

Paper

ESC Congress 2026 AbstractOct 26

Blood-cell mutation worsened aortic aneurysms in mice

After bone marrow transplantation and four weeks of hormone infusion, mice with an Asxl1 mutation developed more aneurysms and ruptures than controls.After bone marrow transplantation and four weeks of hormone infusion, mice with an Asxl1 mutation developed more aneurysms and ruptures than controls.

Mouse studyAbdominal aortic aneurysm

Paper

medRxivOct 1

ASXL1-mutant clonal hematopoiesis links to aortic valve disease

In cohort data and cell models, ASXL1 mutations tracked with incident aortic stenosis and promoted valvular calcification that was reduced by IL-1 or IL-6 inhibition.In cohort data and cell models, ASXL1 mutations tracked with incident aortic stenosis and promoted valvular calcification that was reduced by IL-1 or IL-6 inhibition.

Preprint: cohort study of 449,109 peopleASXL1

Paper

Journal of Thoracic OncologySep 29

ASXL1 clonal hematopoiesis is linked to lung cancer risk

In population cohorts, high variant allele fraction ASXL1 mutations were associated with an increased lung cancer hazard ratio of 3.2 among ever-smokers.In population cohorts, high variant allele fraction ASXL1 mutations were associated with an increased lung cancer hazard ratio of 3.2 among ever-smokers.

Cohort study in peopleClonal hematopoiesis of indeterminate potential

Paper

Frontiers in NeurologyMay 14