Stage 4 cardiovascular-kidney-metabolic syndrome

1. Android-to-gynoid lean mass ratio is associated with stage 4 cardiovascular-kidney-metabolic syndrome in humans (OR 1.83, 95% CI 1.34–2.50).

   “Higher AGLR was associated with stage 4 of CKM syndrome (OR = 1.83, 95% CI: 1.34‒2.50, p < 0.001).”

   Humansn = 7,399

   Association between android-to-gynoid lean mass ratio and advanced cardiovascular-kidney-metabolic syndrome, and the cross-sectional association decomposition of estimated glucose disposal rate

   Clinics (Sao Paulo, Brazil)·15 Oct 2026

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1. Moderate-to-vigorous physical activity lowers the risk of stage 4 cardiovascular-kidney-metabolic syndrome in humans (730-1,920 vs. ≤402 MET-minutes/week).

   “Women with moderate MVPA levels (730-1,920 vs. ≤402 MET-minutes/week) demonstrated lower odds of stage 4 CKM syndrome.”

   Humans730-1,920 vs. ≤402 MET-minutes/weekfemales

   Cardiovascular-Kidney-Metabolic (CKM) Syndrome Development and Physical Activity Patterns Among Women of Reproductive Age: An All of US Research Program Study

   AHA Scientific Sessions 2025 abstract·3 Nov 2025

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