Papers on ASXL1 CHIP

8 papers3 new in 30 days

Monday, October 26

ESC Congress 2026 AbstractOct 26

Blood mutations linked to heart, kidney, and metabolic disease

Participants with age-related expansion of mutated blood cells had an adjusted hazard ratio of 1.11 for progression to syndrome stage 4 compared with participants without…Participants with age-related expansion of mutated blood cells had an adjusted hazard ratio of 1.11 for progression to syndrome stage 4 compared with participants without the condition.

Blood cells cluster densely beside a thick-walled heart and scarred kidney, while fewer cells sit near smaller, intact heart and kidney sections.

Cohort · 433,924 peopleStage 4 cardiovascular-kidney-metabolic syndrome

Paper

ESC Congress 2026 AbstractOct 26

Blood-cell mutation worsened aortic aneurysms in mice

After bone marrow transplantation and four weeks of hormone infusion, mice with an Asxl1 mutation developed more aneurysms and ruptures than controls.After bone marrow transplantation and four weeks of hormone infusion, mice with an Asxl1 mutation developed more aneurysms and ruptures than controls.

A swollen, ruptured aorta surrounded by many immune cells sits beside a smaller intact aorta with fewer cells and a laboratory mouse.

Mouse studyAbdominal aortic aneurysm

Paper

Thursday, October 1

medRxivOct 1

ASXL1-mutant clonal hematopoiesis links to aortic valve disease

In cohort data and cell models, ASXL1 mutations tracked with incident aortic stenosis and promoted valvular calcification that was reduced by IL-1 or IL-6 inhibition.In cohort data and cell models, ASXL1 mutations tracked with incident aortic stenosis and promoted valvular calcification that was reduced by IL-1 or IL-6 inhibition.

Multivariable-adjusted associations of CHIP and key CHIP subtypes with incident aortic stenosis in the UK Biobank Forest plot of hazard ratios for risk of incident aortic stenosis by CHIP status in…

Preprint: cohort study of 449,109 peopleASXL1

Paper

Tuesday, September 29

Journal of Thoracic OncologySep 29

ASXL1 clonal hematopoiesis is linked to lung cancer risk

In population cohorts, high variant allele fraction ASXL1 mutations were associated with an increased lung cancer hazard ratio of 3.2 among ever-smokers.In population cohorts, high variant allele fraction ASXL1 mutations were associated with an increased lung cancer hazard ratio of 3.2 among ever-smokers.