medRxiv
ASXL1-mutant clonal hematopoiesis links to aortic valve disease
In cohort data and cell models, ASXL1 mutations tracked with incident aortic stenosis and promoted valvular calcification that was reduced by IL-1 or IL-6 inhibition.In cohort data and cell models, ASXL1 mutations tracked with incident aortic stenosis and promoted valvular calcification that was reduced by IL-1 or IL-6 inhibition.
Preprint: cohort study of 449,109 peopleASXL1