What does the research say about Large CHIP?

Large CHIP

There is 1 paper on large CHIP in aging research: 1 observational study in people. The newest story, Oct 26, 2026: “Blood mutations linked to heart, kidney, and metabolic disease”.

Biomarker

1 paper studies it11 more mention it

3 new papers in 30 daysSee all 12

Humans1

Latest

9 papers in 12 months

ESC Congress 2026 AbstractOct 26

Blood mutations linked to heart, kidney, and metabolic disease

Participants with age-related expansion of mutated blood cells had an adjusted hazard ratio of 1.11 for progression to syndrome stage 4 compared with participants without…Participants with age-related expansion of mutated blood cells had an adjusted hazard ratio of 1.11 for progression to syndrome stage 4 compared with participants without the condition.

Cohort · 433,924 peopleStage 4 cardiovascular-kidney-metabolic syndrome

Paper

Frontiers in EndocrinologyOct 23

Large groups of mutated blood cells linked to cardiovascular death

Large mutated blood-cell groups were linked to a higher relative rate of cardiovascular death: a hazard ratio of 1.24 versus people without the condition.Large mutated blood-cell groups were linked to a higher relative rate of cardiovascular death: a hazard ratio of 1.24 versus people without the condition.

Cohort · 288,384 peopleMechanisms

Paper

medRxivOct 1

ASXL1-mutant clonal hematopoiesis links to aortic valve disease

In cohort data and cell models, ASXL1 mutations tracked with incident aortic stenosis and promoted valvular calcification that was reduced by IL-1 or IL-6 inhibition.In cohort data and cell models, ASXL1 mutations tracked with incident aortic stenosis and promoted valvular calcification that was reduced by IL-1 or IL-6 inhibition.

Preprint: cohort study of 449,109 peopleASXL1

Paper

European Heart JournalAug 30