non-DNMT3A CHIP

Biomarker1 paper1 finding

  • Humans1

Associations

1

Stage 4 CKM syndrome progression

upin humans1

1 study
  1. non-DNMT3A CHIP predicts stage 4 CKM syndrome progression in humans (aHR 1.24, 95% CI 1.17-1.31).

    Humansmultivariable-adjustedmedian 13.5 yearsn = 451,460

    Clonal haematopoiesis and cardiovascular-kidney-metabolic syndrome: a cohort study · European heart journal · 30 Aug 2026

Stage 4 CKM syndrome progression →

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medRxivHumansPreprint

ASXL1-mutant clonal hematopoiesis links to aortic valve disease

In cohort data and cell models, ASXL1 mutations tracked with incident aortic stenosis and promoted valvular calcification that was reduced by IL-1 or…In cohort data and cell models, ASXL1 mutations tracked with incident aortic stenosis and promoted valvular calcification that was reduced by IL-1 or IL-6 inhibition.