Astrocyte activation

Biomarker

1 paper1 finding

Animals1

Interventions

Agathobaculum butyriciproducens

downin mice1

1 study

Agathobaculum butyriciproducens decrease astrocyte activation in mice.
“Age-related activation of astrocytes in the cortex of layers III-V of the aged brain was reduced following SR79 administration.”
Animalsaged micecortex
Agathobaculum butyriciproducens improves ageing-associated cognitive impairment in mice
Life sciences12 Jan 2024

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NutrientsYesterday

Multidimensional Neuroprotective Effects of Combined Ubisol-Q10 and Ashwagandha (Withania somnifera) in Male and Female 5XFAD Mice

Experiments in miceInterventions

Paper

Brain, Behavior, and Immunity15 Oct

Aged mice changed behaviour after sepsis without broad inflammation

Researchers followed three-month-old and 18-month-old mice through seven days after sepsis; aged mice showed altered nesting and social behaviour despite comparable…Researchers followed three-month-old and 18-month-old mice through seven days after sepsis; aged mice showed altered nesting and social behaviour despite comparable illness severity.

Experiments in young and aged mice, against young mice with comparable illness severityInflammation

Limit: Brain measurements could have missed earlier inflammation contributing to behavioral changes

Paper

Journal of Neuroinflammation14 Oct

Protein loss promotes age-linked brain cell activation in mice

In experiments, aged mice lacking the protein showed stronger age-linked brain cell activation, but no obvious loss of nerve insulation or faster decline in movement.In experiments, aged mice lacking the protein showed stronger age-linked brain cell activation, but no obvious loss of nerve insulation or faster decline in movement.

Experiments in adult and aged mice, against aged control miceMechanisms

Limit: The experiments did not distinguish adaptive activation from early, compensated persistent activation

Paper

Neurobiology of Aging23 Sep