APOE ɛ4

Biomarker

1 paper

  • Humans1

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Alzheimer's & Dementia

Depression and sleep links to protein build-up varied by genetic risk

An observational study of 110 adults aged 65–88 with depression found separate, additive links to amyloid, a protein, only in carriers of a genetic variant.An observational study of 110 adults aged 65–88 with depression found separate, additive links to amyloid, a protein, only in carriers of a genetic variant.

Cohort study of 110 peopleDepression
medRxiv

Social isolation linked to blood marker of nerve-cell injury

Persistent severe isolation was linked to higher levels of a blood marker of nerve-cell injury than no isolation, with a statistical association estimate of 0.31.Persistent severe isolation was linked to higher levels of a blood marker of nerve-cell injury than no isolation, with a statistical association estimate of 0.31.

Preprint: cohort study of 3,862 peoplePopulations
Journal of Alzheimer's Disease

Social isolation links to amyloid pathology and lower cognition

In 957 non-demented adults, social isolation was associated with lower cognitive scores, decreased cerebrospinal fluid amyloid-beta levels, and higher tau-to-amyloid…In 957 non-demented adults, social isolation was associated with lower cognitive scores, decreased cerebrospinal fluid amyloid-beta levels, and higher tau-to-amyloid ratios.

Cross-sectional study of 957 peoplePopulations