1 paper
National Institute on AgingUS$7.2m
Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease
National Institute on AgingUniversity of California, San DiegoUS$728.7k2020–2026
National Institute on AgingUniversity of California-irvineUS$127.3k2020–2025
National Institute on AgingIcahn School of Medicine at Mount SinaiUS$584.8k2019–2025
Among 286 adults with sleep apnoea, 68 developed cognitive impairment over a median 4.18 years; higher levels of two blood markers were linked to risk.Among 286 adults with sleep apnoea, 68 developed cognitive impairment over a median 4.18 years; higher levels of two blood markers were linked to risk.
Over a median 11.45 years, major heart and brain blood-vessel events affected 49.40% with both conditions, versus 17.00% without sleep apnoea and with normal lung…Over a median 11.45 years, major heart and brain blood-vessel events affected 49.40% with both conditions, versus 17.00% without sleep apnoea and with normal lung function.
Participants with both conditions had a hazard ratio—a comparison of event rates over time—of 1.78 for cardiovascular events versus those with neither.Participants with both conditions had a hazard ratio—a comparison of event rates over time—of 1.78 for cardiovascular events versus those with neither.
Across two validation cohorts of over 22,000 patients, an AI score from overnight heart traces yielded hazard ratios of 2.03 and 2.72 for atrial fibrillation.Across two validation cohorts of over 22,000 patients, an AI score from overnight heart traces yielded hazard ratios of 2.03 and 2.72 for atrial fibrillation.