2 papers1 finding
Multi-modal MRI
upin silico1
Multi-modal MRI predicts amyloid pathology in silico (accuracy 0.71, sensitivity 0.70, specificity 0.72).
“On evaluation using the validation dataset, the model achieved a sensitivity of 0.70, specificity of 0.72, and accuracy of 0.71 in detecting amyloid positivity.”
In silicousing T1- and T2-weighted MRI to synthesize amyloid pathology imagesbrainn = 149
AI‐driven Amyloid Pathology Detection Using Multi‐modal MRI: A Proof of Concept Study
AAIC 2025 abstract24 Dec 2025
National Institute on AgingUS$2.6m
A cross-sectional analysis of 15,612 adults aged 55–80 screened for Alzheimer’s trials found blood marker differences between racial and ethnic groups.A cross-sectional analysis of 15,612 adults aged 55–80 screened for Alzheimer’s trials found blood marker differences between racial and ethnic groups.
In a study of App SAA knock-in mice from 4 to 19 months, animals developed progressive amyloid pathology, neuroinflammation, biomarker shifts, and synaptic loss.In a study of App SAA knock-in mice from 4 to 19 months, animals developed progressive amyloid pathology, neuroinflammation, biomarker shifts, and synaptic loss.
In 5xFAD mice, 16 weeks of voluntary wheel running altered fat tissue but produced modest hippocampal changes and failed to improve amyloid pathology or memory.In 5xFAD mice, 16 weeks of voluntary wheel running altered fat tissue but produced modest hippocampal changes and failed to improve amyloid pathology or memory.
Treatment with astrocyte-conditioned solution also rescued cognitive deficits and lowered inflammation in mouse models of Alzheimer's disease.Treatment with astrocyte-conditioned solution also rescued cognitive deficits and lowered inflammation in mouse models of Alzheimer's disease.
In 957 non-demented adults, social isolation was associated with lower cognitive scores, decreased cerebrospinal fluid amyloid-beta levels, and higher tau-to-amyloid…In 957 non-demented adults, social isolation was associated with lower cognitive scores, decreased cerebrospinal fluid amyloid-beta levels, and higher tau-to-amyloid ratios.