Tau pathology
Biomarker1 paper1 finding
- Cells1
Effects
1Cognitive function
downin humans1
1 study
Cognitive function
downin humans1
Tau pathology impairs cognitive function in humans (β = -0.439).
Humansindependent of APOE
APOE and amyloid-tau pathology in cognitively unimpaired older adults · Alzheimer's & dementia (Amsterdam, Netherlands) · 1 Jul 2026
Funding
National Institute on AgingUS$3.3m7 grants since 2019
National Institute on AgingPennsylvania State Univ Hershey Med CtrUS$236k2026–2028
National Institute on AgingUniv of Massachusetts Med Sch WorcesterUS$419.9k2026–2031
National Institute on AgingUniversity of Alabama at BirminghamUS$459.6k2022–2027
Role of clearance of toxic metabolites in mitochondrial and tau pathology
National Institute on AgingColumbia University Health SciencesUS$731k2023–2028
Associations among monoamines, tau pathology and emotional memory in aging
National Institute on AgingBrandeis UniversityUS$36.5k2025–2028
Tracking the origin of tau pathology: dovetailing (pre-)preclinical biomarker trajectories
National Institute on AgingMassachusetts General HospitalUS$693k2019–2031
National Institute on AgingUniversity of PennsylvaniaUS$770.2k2022–2027
Latest
137Hypothalamic tau impairs pair bonding in male prairie voles
Expressing mutant tau in the paraventricular hypothalamus stopped 18-month-old male prairie voles from forming selective bonds and altered their…Expressing mutant tau in the paraventricular hypothalamus stopped 18-month-old male prairie voles from forming selective bonds and altered their oxytocin signaling.
Higher education is linked to lower Alzheimer pathology in women
In an autopsy cohort of 2,592 older adults, higher education was linked to lower amyloid and tau pathology in female participants but not in males.In an autopsy cohort of 2,592 older adults, higher education was linked to lower amyloid and tau pathology in female participants but not in males.
High neutrophil-to-lymphocyte ratio predicts cognitive decline
During five years of follow-up, 42.55% of older adults with high ratios progressed to mild cognitive impairment or dementia compared with 30.82% with…During five years of follow-up, 42.55% of older adults with high ratios progressed to mild cognitive impairment or dementia compared with 30.82% with normal ratios.
Directly converted human neuronal spheroids preserve donor age and model Alzheimer disease
The three-dimensional cell platform maintains biological aging markers while spontaneously developing hallmark pathologies of sporadic Alzheimer…The three-dimensional cell platform maintains biological aging markers while spontaneously developing hallmark pathologies of sporadic Alzheimer disease.
Microglia-derived extracellular vesicle content as a biomarker for early detection of Alzheimer's disease
Astrocytic secretome enhances hippocampal neurogenesis and spatial memory in mice
Treatment with astrocyte-conditioned solution also rescued cognitive deficits and lowered inflammation in mouse models of Alzheimer's disease.Treatment with astrocyte-conditioned solution also rescued cognitive deficits and lowered inflammation in mouse models of Alzheimer's disease.
APOE and amyloid-tau pathology in cognitively unimpaired older adults
Immune cell profiles predict cognitive decline in older adults
In 4,464 cognitively normal older adults, a higher immune risk score predicted incident cognitive impairment or dementia with a hazard ratio of 1.63…In 4,464 cognitively normal older adults, a higher immune risk score predicted incident cognitive impairment or dementia with a hazard ratio of 1.63 over six years.
Aging rhesus macaques display distinct fluid proteomic signatures of senescence and neuropathology
Plasma proteins tracked aging and amyloid pathology more closely than cerebrospinal fluid across the non-human primate lifespan.Plasma proteins tracked aging and amyloid pathology more closely than cerebrospinal fluid across the non-human primate lifespan.