2 papers5 findings
[18F]-FEOBV uptake
downin humans1
Amyloid accumulation decreases [18F]-FEOBV uptake in humans (p < 0.005).
“adults with DS displayed lower [ 18 F]‐FEOBV uptake related to higher amyloid accumulation, showing a more significant decline compared to amyloid‐matched controls ( p < 0.005).”
Humansin adults with Down syndrome compared to amyloid-matched controlsbrain
AAIC 2025 abstract24 Dec 2025
Health-related resource use
no changein humans1
Amyloid accumulation has no effect on health-related resource use in humans.
“There were no between‐group differences in the rate of change in participation in any outcomes over time.”
Humansover time
AAIC 2025 abstract23 Dec 2025
18f-smbt-1
upin humans1
18f-smbt-1 predicts amyloid accumulation in humans (1.20CL/yr vs 0.01CL/yr, p = 0.001).
“In CU A‐ participants with high 18 F‐SMBT‐1 retention, significantly higher Ab accumulation rates were observed compared to low 18 F‐SMBT1 (1.20CL/yr vs 0.01CL/yr, respectively, p = 0.001)”
Humansin cognitively unimpaired amyloid-negative (CU A-) individualsbrainn = 81
AAIC 2025 abstract7 Jan 2026
Volunteering
downin humans1
Amyloid accumulation is associated with volunteering in humans (OR±SE=0.448 ±0.117).
“less likely to volunteer (OR±SE=0.448 ±0.117)”
Humanscontrolling for covariates
AAIC 2025 abstract23 Dec 2025
Paid employment
upin humans1
Amyloid accumulation is associated with paid employment in humans (OR±SE=1.886±0.598).
“A4 participants were at baseline more likely than LEARN to participate in paid employment (OR±SE=1.886±0.598)”
Humanscontrolling for covariates
AAIC 2025 abstract23 Dec 2025
In 64 older adults tracked for 2.6 years, lower rapid eye movement sleep was linked to a faster drop in a blood marker of Alzheimer's disease.In 64 older adults tracked for 2.6 years, lower rapid eye movement sleep was linked to a faster drop in a blood marker of Alzheimer's disease.
In an observational study of 1,110 people, living in more deprived areas was associated with lower cognitive scores and more amyloid build-up in unimpaired brains.In an observational study of 1,110 people, living in more deprived areas was associated with lower cognitive scores and more amyloid build-up in unimpaired brains.
A two-year randomised trial in 1,260 older adults at risk of dementia found no clear evidence that starting blood markers altered cognitive benefits.A two-year randomised trial in 1,260 older adults at risk of dementia found no clear evidence that starting blood markers altered cognitive benefits.
In cognitively unimpaired older adults, intermediate amyloid burden showed lower dopamine-transporter deviation scores than amyloid-positive status, with an adjusted…In cognitively unimpaired older adults, intermediate amyloid burden showed lower dopamine-transporter deviation scores than amyloid-positive status, with an adjusted difference of −0.582.