18f-smbt-1

1. Amyloid-beta deposition increases 18f-smbt-1 in humans.

   “Aβ+ve CU individuals, had significantly higher regional 18 F‐SMBT‐1 binding than Aβ‐ve CU participants.”

   Humanscognitively unimpaired participantsbrain

   Assessing reactive astrogliosis in aging and across the Alzheimer's disease spectrum with SMBT‐1

   AAIC 2025 abstract·26 Dec 2025

1. Amyloid-beta is associated with 18f-smbt-1 in humans.

   “18 F‐SMBT‐1 binding was higher in CU A+ compared to the CU A‐ in most regions”

   Humansin cognitively unimpaired amyloid-positive (CU A+) individuals compared to CU A-brain

   Reactive Astrogliosis predicts Amyloid Accumulation before the Preclinical Stage of Alzheimer's Disease

   AAIC 2025 abstract·7 Jan 2026

More on Amyloid-beta

1. 18f-smbt-1 predicts amyloid accumulation in humans (1.20CL/yr vs 0.01CL/yr, p = 0.001).

   “In CU A‐ participants with high 18 F‐SMBT‐1 retention, significantly higher Ab accumulation rates were observed compared to low 18 F‐SMBT1 (1.20CL/yr vs 0.01CL/yr, respectively, p = 0.001)”

   Humansin cognitively unimpaired amyloid-negative (CU A-) individualsbrainn = 81

   Reactive Astrogliosis predicts Amyloid Accumulation before the Preclinical Stage of Alzheimer's Disease

   AAIC 2025 abstract·7 Jan 2026

More on Amyloid accumulation

1. 18f-smbt-1 is associated with tau deposition in humans.

   “18 F‐SMBT‐1 binding was associated with an early, non‐canonical/Aβ‐independent high tau deposition.”

   Humanslongitudinal cohort with cardiovascular risk factorsbrain

   Assessing reactive astrogliosis in aging and across the Alzheimer's disease spectrum with SMBT‐1

   AAIC 2025 abstract·26 Dec 2025

1. 18f-smbt-1 predicts amyloid-beta accumulation in humans.

   “high 18 F‐SMBT‐1 in Aβ‐ve CU is predictive of future Aβ accumulation.”

   Humanspreclinical AD / Aβ-ve cognitively unimpairedbrain

   Assessing reactive astrogliosis in aging and across the Alzheimer's disease spectrum with SMBT‐1

   AAIC 2025 abstract·26 Dec 2025

1. 18f-smbt-1 is associated with amyloid-beta deposition in humans.

   “18 F‐SMBT‐1 was highly associated with Aβ load, and much less with tau.”

   Humansacross AD continuumbrain

   Assessing reactive astrogliosis in aging and across the Alzheimer's disease spectrum with SMBT‐1

   AAIC 2025 abstract·26 Dec 2025