[18F]-FEOBV uptake

1. Amyloid accumulation decreases [18F]-FEOBV uptake in humans (p < 0.005).

   “adults with DS displayed lower [ 18 F]‐FEOBV uptake related to higher amyloid accumulation, showing a more significant decline compared to amyloid‐matched controls ( p < 0.005).”

   Humansin adults with Down syndrome compared to amyloid-matched controlsbrain

   Association of cholinergic integrity measured by [ ¹⁸ F]‐fluoroethoxybenzovesamicol with age and amyloid burden in adults with Down syndrome

   AAIC 2025 abstract·24 Dec 2025

More on Amyloid accumulation

1. Age decreases [18F]-FEOBV uptake in humans (p < 0.005).

   “significant age x group interaction revealing a greater reduction in adults with DS compared to controls ( p < 0.005).”

   Humansin adults with Down syndrome compared to controlsbrain

   Association of cholinergic integrity measured by [ ¹⁸ F]‐fluoroethoxybenzovesamicol with age and amyloid burden in adults with Down syndrome

   AAIC 2025 abstract·24 Dec 2025

1. Down syndrome increases [18F]-FEOBV uptake in humans (p < 0.001).

   “Adults with DS exhibited increased [ 18 F]‐FEOBV uptake in the cerebellum, brainstem, thalamus, and cortical regions compared to age‐matched neurotypical controls ( p < 0.001).”

   HumansDown syndrome vs age-matched neurotypical controlsbrain

   Association of cholinergic integrity measured by [ ¹⁸ F]‐fluoroethoxybenzovesamicol with age and amyloid burden in adults with Down syndrome

   AAIC 2025 abstract·24 Dec 2025

More on Down syndrome