Association of cholinergic integrity measured by [ ¹⁸ F]‐fluoroethoxybenzovesamicol with age and amyloid burden in adults with Down syndrome

Abstract

Background: Adults with Down syndrome (DS) are at increased risk for Alzheimer's disease (AD) due to APP triplication. Cholinergic system degeneration underlies many AD‐related cognitive deficits, but cholinergic integrity in adults with DS is not well defined.