α-synuclein accumulation

2 papers2 findings

Animals1
Model organisms1

Interventions

2

AAV1-NAC32

downin rats1

1 study

AAV1-NAC32 decreases α-synuclein accumulation in rats.
“NAC32 intrabody expression in the substantia nigra significantly reduced αSyn accumulation”
AnimalsAAV1-mediated NAC32 intrabody expressionsubstantia nigra
AAV-mediated intracerebral expression of an α-synuclein-targeting intrabody improves motor functions in aged rats
Scientific reports7 Jan 2026

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TEMPORIN-1CEA

downin worms1

1 study

TEMPORIN-1CEA decreases α-synuclein accumulation in worms.
“peptides could effectively reduce the accumulation of α-synuclein”
Model organismsin NL5901 nematodes
Temporin-1CEa and its Analog LK2(6)A(L) Confer Neuroprotective Effects in Parkinson's Disease Model by Attenuating Neuroinflammation Via the NF-κB and MAPK Signaling Pathways
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology6 Oct 2025

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Latest

2 in 12 months

Frontiers in Pharmacology27 Feb

Miquelianin and spiraeoside from Filipendula ulmaria mitigate α-synuclein accumulation in C.elegans and reduce the expression of neuroinflammatory cytokines in human microglia

Experiments in wormsInterventions

Scientific Reports8 Jan

AAV-mediated intracerebral expression of an α-synuclein-targeting intrabody improves motor functions in aged rats

Experiments in ratsInterventions

Journal of Neuroimmune Pharmacology6 Oct

Temporin-1CEa and its Analog LK2(6)A(L) Confer Neuroprotective Effects in Parkinson's Disease Model by Attenuating Neuroinflammation Via the NF-κB and MAPK Signaling Pathways

Experiments in wormsParkinson's disease