2 papers
Over a median 13.48 years, 2,567 UK Biobank participants progressed from stage 0 or 1 to stage 2 or 3 of the syndrome.Over a median 13.48 years, 2,567 UK Biobank participants progressed from stage 0 or 1 to stage 2 or 3 of the syndrome.
A 12-month chronic stress experiment in mice found that the compound medicine eased signs of aging and reduced inflammation across several tissues.A 12-month chronic stress experiment in mice found that the compound medicine eased signs of aging and reduced inflammation across several tissues.
In six-month-old mice with accelerated aging, ER272 was linked to better cognition and preserved markers of new brain cells in males, but showed limited effects in…In six-month-old mice with accelerated aging, ER272 was linked to better cognition and preserved markers of new brain cells in males, but showed limited effects in females.
Experiments with three-layer vessels built from human cells found that support cells increased several vascular disease features in a model of Hutchinson-Gilford progeria…Experiments with three-layer vessels built from human cells found that support cells increased several vascular disease features in a model of Hutchinson-Gilford progeria syndrome.
An animal experiment in genetically engineered mice found that the variant prevented characteristic tissue changes and modestly increased median lifespan.An animal experiment in genetically engineered mice found that the variant prevented characteristic tissue changes and modestly increased median lifespan.
In a PolgA-mutant mouse model, gut microbiota reduced systemic mitochondrial function while driving energy-demanding immune remodeling and protein synthesis through mTOR…In a PolgA-mutant mouse model, gut microbiota reduced systemic mitochondrial function while driving energy-demanding immune remodeling and protein synthesis through mTOR signaling.