Smoking is associated with accelerated ageing in humans.
“Here we show significant associations between detected accelerated ageing and specific chronic diseases, including multiple sclerosis and chronic obstructive pulmonary disease, as well as lifestyle factors such as smoking and physical activity.”
Chronic obstructive pulmonary disease is associated with accelerated ageing in humans.
“Here we show significant associations between detected accelerated ageing and specific chronic diseases, including multiple sclerosis and chronic obstructive pulmonary disease”
Multiple sclerosis is associated with accelerated ageing in humans.
“Here we show significant associations between detected accelerated ageing and specific chronic diseases, including multiple sclerosis and chronic obstructive pulmonary disease”
In laboratory experiments, depleting the protein triggered premature senescence, a state in which cells stop dividing, in human umbilical vein cells.In laboratory experiments, depleting the protein triggered premature senescence, a state in which cells stop dividing, in human umbilical vein cells.
Experiments in serially passaged, senescent HUVECs, against vector-control senescent HUVECsMechanisms
Limit: Youthfulness was inferred from senescence markers rather than direct tests of restored cell function
Experiments in mice producing a progeria-linked protein in heart muscle cells found that restoring an RNA-marking protein partly reduced abnormal heart changes.Experiments in mice producing a progeria-linked protein in heart muscle cells found that restoring an RNA-marking protein partly reduced abnormal heart changes.
Experiments in Zmpste24−/− mice, 2 months, against AAV-cTnT-GFP-treated miceMechanisms
Limit: Reduced heart fibrosis does not directly demonstrate restored pumping function
Longer telomeres were linked to lower odds of interstitial lung disease, with an odds ratio of 0.59 per standard-deviation increase in length.Longer telomeres were linked to lower odds of interstitial lung disease, with an odds ratio of 0.59 per standard-deviation increase in length.
Over a median 13.48 years, 2,567 UK Biobank participants progressed from stage 0 or 1 to stage 2 or 3 of the syndrome.Over a median 13.48 years, 2,567 UK Biobank participants progressed from stage 0 or 1 to stage 2 or 3 of the syndrome.
A 12-month chronic stress experiment in mice found that the compound medicine eased signs of aging and reduced inflammation across several tissues.A 12-month chronic stress experiment in mice found that the compound medicine eased signs of aging and reduced inflammation across several tissues.