Aβ plaque burden

Biomarker

2 papers1 finding

  • Animals2

Interventions

1

Methionine restriction

downin mice1

1 study
  1. Methionine restriction decreases Aβ plaque burden in mice.

    “reduced neuronal loss, decreased Aβ plaque burden, increased dendritic spine density, and lower astrocyte abnormal activation.”

    Animalsin APP/PS1 micebrain4 months

    Methionine restriction inhibits the TGF-β1/CCN2/NF-κB pathway to attenuate astrocyte inflammation and cognitive impairment in the APP/PS1 mice

    International immunopharmacology15 Sep 2025

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Aging Cell

Stomach surgery reduced Alzheimer’s-related plaques in mice

A 12-month experiment in female mice modelling Alzheimer’s disease found fewer plaques in the brain’s outer layer after stomach-reducing surgery than after a comparison…A 12-month experiment in female mice modelling Alzheimer’s disease found fewer plaques in the brain’s outer layer after stomach-reducing surgery than after a comparison operation.

Experiments in female 3xTg-AD mice, 12 months, against sham-operated miceAlzheimer's disease

Limit: High mortality restricted Western-diet plaque analyses to survivors, potentially biasing the apparent benefit