4 papers
In mouse and human neurons, depleting POLK reduced repair-associated DNA synthesis and induced senescence-like stress, while augmenting POLK lowered DNA damage markers.In mouse and human neurons, depleting POLK reduced repair-associated DNA synthesis and induced senescence-like stress, while augmenting POLK lowered DNA damage markers.
Lipid nanoparticle delivery of base-editing mRNA restored DNA repair and heterochromatin structure in human neuromuscular models of premature aging.Lipid nanoparticle delivery of base-editing mRNA restored DNA repair and heterochromatin structure in human neuromuscular models of premature aging.
Studying sporadic ALS astrocyte models, researchers found TDP43 dysfunction impaired adenosine deaminase, disrupting purines and raising P16 levels while blunting…Studying sporadic ALS astrocyte models, researchers found TDP43 dysfunction impaired adenosine deaminase, disrupting purines and raising P16 levels while blunting 53BP1-mediated repair.