Single-cell mapping of the fallopian tube reveals a genomically unstable secretory cell state enriched in carriers of germline BRCA1/2 mutations
bioRxiv
Abstract
Carriers of germline BRCA1 or BRCA2 alterations have a substantially increased lifetime risk of high-grade serous ovarian carcinoma (HGSOC), which originates from the secretory cells of the fallopian tube.
The paper
Yaniv Eyal-Lubling, Maria Vias, Katarzyna Kania, Filipe Correia Martins
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Dimana Kaludova, James Hall, Robin Crawford, Rutendo Nyagumbo, Sophia Ward, Svetlana Khoronenkova, Samuel Aparicio, Charles Swanton, Mercedes Jimenez Linan, James D. Brenton,University of Cambridge
bioRxiv · 27 Aug 2026 · CC BY · Preprint, not peer-reviewed
