4-hydroxy-2-nonenal adducts

1. Nordihydroguaiaretic acid decreases 4-hydroxy-2-nonenal adducts in mice.

   “Administration of nordihydroguaiaretic acid (NDGA), an antioxidant that functions by inhibiting lipid peroxidation, markedly reduced 4-HNE adduct formation in the nuclear inclusions of R6/2 striatal neurons.”

   Animalsin R6/2 striatal neuronsstriatal neurons

   Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington's disease mice

   Acta neuropathologica·16 Dec 2010

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