Cognitive training improves MoCA scores in older adults with MCI
In a randomized trial, added cognitive training improved MoCA scores over controls by β = 0.525 at 3 months and β = 1.627 at 12 months.
Research Square
In a randomized controlled trial of older adults with mild cognitive impairment, researchers tested whether adding structured cognitive training to a multimodal program enhanced cognitive performance. The trial enrolled 146 participants, assigning 73 to an intervention group and 73 to an active control group. Both groups received cognitive-health education, home-based cognitive activities, and standardized physical exercise. The intervention group also completed 12 weeks of supervised, structured multidomain cognitive training with individualized starting levels and progressive difficulty adjustments. The primary outcome was change in Montreal Cognitive Assessment (MoCA) total score at 3 and 12 months. Compared with controls, the intervention group showed greater MoCA score improvements at 3 months (β = 0.525; 95% CI, 0.227 to 0.822; p = 0.001) and 12 months (β = 1.627; 95% CI, 1.325 to 1.929).
Why it matters
Mild cognitive impairment represents an important transitional state between standard cognitive aging and dementia. Demonstrating sustained improvements from structured non-pharmacological interventions informs clinical approaches to slowing age-related cognitive decline.
Caveats
The findings are reported in a preprint and have not yet undergone peer review. The trial was limited to 146 enrolled participants and evaluated cognitive outcomes through 12 months.
The paper
University of Medicine and Pharmacy at Ho Chi Minh City
Research Square · 30 Sep 2026 · Preprint, not peer-reviewed