Lower cognition in people aged 60 to 69 links to future stroke

In adults aged 60 to 69, low global cognition carried a stroke hazard ratio of 1.86 compared with the highest tertile over 12.3 years.

Journal of the American Heart Association

In a cohort of 4,912 Swedish adults aged 60 and older, lower cognitive performance was linked to an increased risk of first-time stroke over an average 12.3-year follow-up. Researchers examined participants from the Good Aging in Skåne study who had no history of stroke, transient ischemic attack, or dementia at baseline. During the follow-up period, 572 participants experienced a stroke. In fully adjusted models across the full sample, participants in the lowest tertile of perceptual speed had an increased stroke risk (hazard ratio, 1.40). When stratified by age, participants aged 60 to 69 in the lowest tertiles of global cognition (hazard ratio, 1.86), episodic memory (hazard ratio, 1.68), and perceptual speed (hazard ratio, 1.66) each showed elevated stroke risk.

Why it matters

Deficits in specific cognitive domains in early older age may identify individuals with heightened vulnerability to future cerebrovascular events.

Caveats

Because this study is observational, it shows an association rather than direct causation between lower cognitive performance and stroke risk.

The paper

Lower Cognitive Function in People Aged 60 to 69 Years Is Associated With Future Stroke

Lund University

Journal of the American Heart Association · 30 Sep 2026

doi.org/10.1161/jaha.125.048423PubMed 42813560