Xenopus tropicalis

2 papers4 findings

Animals2

Interventions

Triiodothyronine

downECM-related gene expression1upinflammation-related gene expression1no changetail regeneration1downtail regeneration1

1 study

Triiodothyronine increases inflammation-related gene expression in X. tropicalis.
“T3 signaling via TRs inhibits the expression of ECM-related genes while promoting the expression of inflammation-related genes during the blastema formation period.”
Animalssignaling via thyroid hormone receptorstailblastema formation period
Thyroid hormone receptor- and stage-dependent transcriptome changes affect the initial period of Xenopus tropicalis tail regeneration
BMC genomics31 Dec 2024
Triiodothyronine decreases ECM-related gene expression in X. tropicalis.
“T3 signaling via TRs inhibits the expression of ECM-related genes while promoting the expression of inflammation-related genes during the blastema formation period.”
Animalssignaling via thyroid hormone receptorstailblastema formation period
Thyroid hormone receptor- and stage-dependent transcriptome changes affect the initial period of Xenopus tropicalis tail regeneration
BMC genomics31 Dec 2024
Triiodothyronine has no effect on tail regeneration in X. tropicalis.
“T3 treatment at stage 56, while not inducing any measurable tail resorption, inhibited tail regeneration in the wild type but not TRDKO tadpoles.”
Animalstadpoles lacking both thra and thrb (TRDKO)tail
Thyroid hormone receptor- and stage-dependent transcriptome changes affect the initial period of Xenopus tropicalis tail regeneration
BMC genomics31 Dec 2024
Triiodothyronine inhibits tail regeneration in X. tropicalis.
“T3 treatment at stage 56, while not inducing any measurable tail resorption, inhibited tail regeneration in the wild type but not TRDKO tadpoles.”
Animalswild-type tadpolestail
Thyroid hormone receptor- and stage-dependent transcriptome changes affect the initial period of Xenopus tropicalis tail regeneration
BMC genomics31 Dec 2024