Yeast-derived lipids

1. Yeast-derived lipids improve mitochondrial function in flies.

   “while selectively boosting mitochondrial function in memory-critical Kenyon cells.”

   Model organismsKenyon cell

   Regional and Systemic Metabolic Remodeling Promotes Longevity by Bioengineered Yeast-Derived Lipids

   bioRxiv : the preprint server for biology·13 Apr 2026Preprint

1. Yeast-derived lipids decrease unsaturated fatty acid biosynthesis in flies.

   “alongside reduction of unsaturated fatty acid biosynthesis.”

   Model organismsenterocyte

   Regional and Systemic Metabolic Remodeling Promotes Longevity by Bioengineered Yeast-Derived Lipids

   bioRxiv : the preprint server for biology·13 Apr 2026Preprint

1. Yeast-derived lipids increase autophagy and protein turnover gene expression in flies.

   “snRNA-seq identifies transcriptional remodeling in metabolically active enterocytes, including upregulation of autophagy and protein turnover genes”

   Model organismsenterocyte

   Regional and Systemic Metabolic Remodeling Promotes Longevity by Bioengineered Yeast-Derived Lipids

   bioRxiv : the preprint server for biology·13 Apr 2026Preprint

More on Autophagy and protein turnover gene expression

1. Yeast-derived lipids improve intestinal epithelial integrity and barrier function in flies.

   “enhance membrane lipid incorporation, and increase de novo lipid synthesis, thereby improving epithelial structural integrity and barrier function.”

   Model organismsintestinal epithelium

   Regional and Systemic Metabolic Remodeling Promotes Longevity by Bioengineered Yeast-Derived Lipids

   bioRxiv : the preprint server for biology·13 Apr 2026Preprint

1. Yeast-derived lipids extend lifespan in flies.

   “dietary lipids extracted from a genetically engineered long-lived yeast strain robustly extend lifespan in Drosophila”

   Model organismslipids extracted from a genetically engineered long-lived yeast strain

   Regional and Systemic Metabolic Remodeling Promotes Longevity by Bioengineered Yeast-Derived Lipids

   bioRxiv : the preprint server for biology·13 Apr 2026Preprint