XJB-5-131
XJB-5-131 has been studied in 2 papers since 2018: none in people yet, 1 in animals, 1 in cells. The research so far is in animals and cells. The newest paper, Apr 12, 2025: “Attenuation of Cellular Senescence and Improvement of Osteogenic Differentiation Capacity of Human Liver Stem Cells Using Specific Senomorphic and Senolytic Agents”.
None of its findings points the other way.
- 2 independent labs in 1 country
- Funders: National Institute on Aging and others
- 3 of 6 findings with company ties
- Animals1
- Cells1
What did studies of XJB-5-131 find?
5Studies of XJB-5-131 measured 5 outcomes; the most studied are cellular senescence (2 studies), stem cell differentiation (1) and senescence-associated secretory phenotype (SASP) (1).
Cellular senescence
downin human cells1downin mice1
2 studies
Cellular senescence
downin human cells1downin mice1
XJB-5-131 decreases cellular senescence in human cells.
“chronic treatment with the senomorphic XJB-5-131 or the senolytics cocktail D + Q reduced the number of senescent cells”
Cellsexpansion in culturesenomorphicliver
Stem cell reviews and reports
XJB-5-131 decreases cellular senescence in mice.
“Chronic treatment of Ercc1-/∆ mice with the mitochondrial-targeted radical scavenger XJB-5-131 attenuated oxidative DNA damage, senescence and age-related pathology.”
AnimalsErcc1-/∆ mice
Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging
Redox biology
Stem cell differentiation
upin human cells1
1 study
Stem cell differentiation
upin human cells1
XJB-5-131 improves stem cell differentiation in human cells.
“treatment with XJB-5-131 and D + Q improved the capacity of HLSCs to undergo osteogenic differentiation following extensive in vitro expansion”
Cellsfollowing extensive in vitro expansionliver
Stem cell reviews and reports
Senescence-associated secretory phenotype (SASP)
downin human cells1
1 study
Senescence-associated secretory phenotype (SASP)
downin human cells1
XJB-5-131 decreases senescence-associated secretory phenotype (SASP) in human cells.
“significantly reduced the expression of senescence-associated genes and several inflammatory SASP factors in later passage HLSCs”
Cellsin later passage HLSCssenomorphicliver
Stem cell reviews and reports
Age-related pathology
downin mice1
1 study
Age-related pathology
downin mice1
XJB-5-131 decreases age-related pathology in mice.
“Chronic treatment of Ercc1-/∆ mice with the mitochondrial-targeted radical scavenger XJB-5-131 attenuated oxidative DNA damage, senescence and age-related pathology.”
AnimalsErcc1-/∆ mice
Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging
Redox biology
Oxidative DNA damage
downin mice1
1 study
Oxidative DNA damage
downin mice1
XJB-5-131 decreases oxidative DNA damage in mice.
“Chronic treatment of Ercc1-/∆ mice with the mitochondrial-targeted radical scavenger XJB-5-131 attenuated oxidative DNA damage, senescence and age-related pathology.”
AnimalsErcc1-/∆ mice
Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging
Redox biology