XEPTM-716 miniproteintm

1. XEPTM-716 miniproteintm decreases low-circularity cell density in humans (p = 0.044).

   Human trialsplit-face vs vehicletopicalstratum granulosum2.5%56 daysfemalesn = 25

   AI-Assisted Quantitative Reflectance Confocal Microscopy Reveals Modulation of Senescence-Associated Epidermal Morphometric Features by a Topical TGF-β Mimetic, XEP™-716 Miniprotein™ · Dermatology and therapy · 1 Oct 2026

Low-circularity cell density →

1. XEPTM-716 miniproteintm decreases intercellular spacing thickness in humans (p = 0.030).

   Human trialsplit-face vs vehicletopicalstratum granulosum2.5%56 daysfemalesn = 25

   AI-Assisted Quantitative Reflectance Confocal Microscopy Reveals Modulation of Senescence-Associated Epidermal Morphometric Features by a Topical TGF-β Mimetic, XEP™-716 Miniprotein™ · Dermatology and therapy · 1 Oct 2026

Intercellular spacing thickness →

1. XEPTM-716 miniproteintm increases normal keratinocyte density in humans (p = 0.028).

   Human trialsplit-face vs vehicletopicalstratum granulosum2.5%56 daysfemalesn = 25

   AI-Assisted Quantitative Reflectance Confocal Microscopy Reveals Modulation of Senescence-Associated Epidermal Morphometric Features by a Topical TGF-β Mimetic, XEP™-716 Miniprotein™ · Dermatology and therapy · 1 Oct 2026

Normal keratinocyte density →