Withaferin a

1. Withaferin a decreases inflammation in mice.

   “Withaferin A-treated HD mice also exhibit significant decrease in inflammatory processes as evident from the decreased microglial activation”

   Animalsin HD micebrain

   Withaferin A Induces Heat Shock Response and Ameliorates Disease Progression in a Mouse Model of Huntington's Disease

   Molecular neurobiology·26 Apr 2021

2. Withaferin a decreases inflammation in mice.

   “accompanied by an alleviation of neuroinflammation”

   Animalsin SOD1(G93A) mice4 mg/kg of body weightpostnatal day 40 until end stage

   Early-stage treatment with Withaferin A reduces levels of misfolded superoxide dismutase 1 and extends lifespan in a mouse model of amyotrophic lateral sclerosis

   Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics·1 Jan 2015

More on Inflammation

1. Withaferin a extends lifespan in mice.

   “Withaferin A treatment to HD mice considerably increased their lifespan”

   Animalsin HD micebrain

   Withaferin A Induces Heat Shock Response and Ameliorates Disease Progression in a Mouse Model of Huntington's Disease

   Molecular neurobiology·26 Apr 2021

2. Withaferin a extends lifespan in mice.

   “extends lifespan in a mouse model of amyotrophic lateral sclerosis”

   Animalsin SOD1(G93A) micespinal cord4 mg/kg of body weightpostnatal day 40 until end stage

   Early-stage treatment with Withaferin A reduces levels of misfolded superoxide dismutase 1 and extends lifespan in a mouse model of amyotrophic lateral sclerosis

   Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics·1 Jan 2015

1. Withaferin a decreases mutant huntingtin aggregates load in mice.

   “global decrease in mutant huntingtin aggregates load accompanied with improvement of striatal function in Withaferin A-treated HD mouse brain”

   Animalsin Withaferin A-treated HD mouse brainbrain

   Withaferin A Induces Heat Shock Response and Ameliorates Disease Progression in a Mouse Model of Huntington's Disease

   Molecular neurobiology·26 Apr 2021

More on Mutant huntingtin aggregates load

1. Withaferin a improves motor behavioral deficits in mice.

   “restored progressive motor behavioral deficits and declined body weight”

   Animalsin HD mice

   Withaferin A Induces Heat Shock Response and Ameliorates Disease Progression in a Mouse Model of Huntington's Disease

   Molecular neurobiology·26 Apr 2021

1. Withaferin a increases HSPB1 in mice.

   “WA treatment triggered robust induction of heat shock protein 25”

   Animalsin SOD1(G93A) mice4 mg/kg of body weight

   Early-stage treatment with Withaferin A reduces levels of misfolded superoxide dismutase 1 and extends lifespan in a mouse model of amyotrophic lateral sclerosis

   Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics·1 Jan 2015

More on HSPB1

1. Withaferin a decreases mortality in mice.

   “reduction in loss of motor neurons resulting in delayed disease progression and mortality”

   Animalsin SOD1(G93A) micespinal cord4 mg/kg of body weightpostnatal day 40 until end stage

   Early-stage treatment with Withaferin A reduces levels of misfolded superoxide dismutase 1 and extends lifespan in a mouse model of amyotrophic lateral sclerosis

   Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics·1 Jan 2015

1. Withaferin a decreases misfolded SOD1 in mice.

   “decrease in levels of misfolded SOD1 species in the spinal cord”

   Animalsin SOD1(G93A) micespinal cord4 mg/kg of body weightpostnatal day 40 until end stage

   Early-stage treatment with Withaferin A reduces levels of misfolded superoxide dismutase 1 and extends lifespan in a mouse model of amyotrophic lateral sclerosis

   Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics·1 Jan 2015

More on Misfolded SOD1