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Misfolded SOD1

Biomarker

1 paper1 finding

  • Animals1

Interventions

1

Withaferin a

downin mice1

1 study

  1. Withaferin a decreases misfolded SOD1 in mice.

    “decrease in levels of misfolded SOD1 species in the spinal cord”

    Animalsin SOD1(G93A) micespinal cord4 mg/kg of body weightpostnatal day 40 until end stage

    Early-stage treatment with Withaferin A reduces levels of misfolded superoxide dismutase 1 and extends lifespan in a mouse model of amyotrophic lateral sclerosis

    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics1 Jan 2015

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