Mutant huntingtin aggregates load

1. Withaferin a decreases mutant huntingtin aggregates load in mice.

   “global decrease in mutant huntingtin aggregates load accompanied with improvement of striatal function in Withaferin A-treated HD mouse brain”

   Animalsin Withaferin A-treated HD mouse brainbrain

   Withaferin A Induces Heat Shock Response and Ameliorates Disease Progression in a Mouse Model of Huntington's Disease

   Molecular neurobiology·26 Apr 2021

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1. Azadiradione decreases mutant huntingtin aggregates load in mice.

   “Azadiradione-treated HD mice brain also exhibited considerable decrease in mutant huntingtin aggregates load”

   AnimalsHD micebrain

   Azadiradione Restores Protein Quality Control and Ameliorates the Disease Pathogenesis in a Mouse Model of Huntington's Disease

   Molecular neurobiology·2 Jan 2018

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