Vitamin a
Intervention2 papers3 findingsPubChem 445354ChEBI 17336
Human studies report lower colorectal and gastric cancer risk with vitamin A; one human study also reports reduced TNF-alpha.
- Humans2
Outcomes
1TNF-alpha
downin humans1Low certainty
1 study
TNF-alpha
downin humans1Low certainty
Vitamin a decreases TNF-alpha in humans (β -12.12, 95% CI -24.71, -0.47).
Humansn = 177
Dietary carotenoids and vitamin A are associated with lower gastric cancer risk and favorable inflammatory and oxidative stress biomarkers: an incident case- control study · Frontiers in nutrition · 7 Sep 2026
Associations
2Colorectal cancer
downin humans1HR 0.75Low certainty
1 study
Colorectal cancer
downin humans1HR 0.75Low certainty
Vitamin a lowers the risk of colorectal cancer in humans (HR = 0.75, 95% CI: 0.60-0.93).
Humans
Vitamin intake and colorectal cancer incidence and mortality: evidence from a large prospective cohort · Frontiers in nutrition · 9 Sep 2026
Gastric cancer
downin humans1OR 0.29Low certainty
1 study
Gastric cancer
downin humans1OR 0.29Low certainty
Vitamin a lowers the risk of gastric cancer in humans (OR 0.29, 95% CI 0.09-0.95).
Humansn = 177
Dietary carotenoids and vitamin A are associated with lower gastric cancer risk and favorable inflammatory and oxidative stress biomarkers: an incident case- control study · Frontiers in nutrition · 7 Sep 2026
Trials
42In trials
Phase 4 · Completed · 2 trials
Infant Death
Phase 4 · Completed · 2 trials
Morbidity
Phase 4 · Completed · 2 trials
Mortality
Phase 4 · Completed · 2 trials
Vitamin A Deficiency
Phase 3 · Completed · 6 trials
Malaria
Phase 3 · Results posted · 3 trials
All 19Fewer
Phase 3 · Completed · 3 trials
Bronchopulmonary Dysplasia
Phase 3 · Completed · 2 trials
Phase 3 · Completed · 2 trials
Phase 3 · Completed · 2 trials
Premature birth
Phase 3 · Completed · 2 trials
Phase 3 · Completed · 2 trials
Phase 3 · Completed · 1 trial
Phase 3 · Completed · 1 trial
Phase 3 · Completed · 1 trial
Phase 3 · Completed · 1 trial
Phase 2 · Status unknown · 2 trials
Phase 2 · Recruiting · 1 trial
Phase 2 · Recruiting · 1 trial
Trial sponsors
5 trialsPhase 435,000 people
1 trialPhase 4720,000 people
National Institute of Allergy and Infectious Diseases
3 trialsPhase 31,803 people
2 trialsPhase 31,202 people
2 trialsPhase 311 people
London School of Hygiene and Tropical Medicine
1 trialPhase 3100,000 people
1 trialPhase 3424 people
1 trialPhase 3321 people
Funding
National Institute on AgingUS$623.6kNational Institute of Neurological Disorders and StrokeUS$480.5k2 grants since 1999
Latest
128Elamipretide improves oocyte quality and restores fertility in aged mice
The peptide also boosted maturation and fertilization in aged human oocytes by activating the vitamin B6 and VEGF pathway.The peptide also boosted maturation and fertilization in aged human oocytes by activating the vitamin B6 and VEGF pathway.