Tlm@cap

1. Tlm@cap protects against osteoarthritis in rats.

   “In an OA rat model, intra-articular TLM@CAP administration effectively alleviated pain, improved gait, and protected against cartilage and subchondral bone destruction.”

   AnimalsOA rat modelintra-articular TLM@CAPcartilage and subchondral bone

   A dual-engineered chondrocyte-targeting tetrahedral DNA-based nanoparticle for improved delivery of metformin and alleviation in osteoarthritis

   Biomaterials·6 Jul 2026

More on Osteoarthritis

1. Tlm@cap decreases pain in rats.

   “In an OA rat model, intra-articular TLM@CAP administration effectively alleviated pain, improved gait, and protected against cartilage and subchondral bone destruction.”

   AnimalsOA rat modelintra-articular TLM@CAPjoint

   A dual-engineered chondrocyte-targeting tetrahedral DNA-based nanoparticle for improved delivery of metformin and alleviation in osteoarthritis

   Biomaterials·6 Jul 2026

More on Pain

1. Tlm@cap improves mitochondrion in rats.

   “In vivo, TLM@CAP outperformed free metformin in restoring mitochondrial function, reducing cellular senescence, and rebalancing extracellular matrix metabolism via AMPK/mTOR pathway activation in senescent chondrocytes.”

   AnimalsOA modelintra-articular TLM@CAPcartilage

   A dual-engineered chondrocyte-targeting tetrahedral DNA-based nanoparticle for improved delivery of metformin and alleviation in osteoarthritis

   Biomaterials·6 Jul 2026

1. Tlm@cap decreases cellular senescence in rats.

   “In vivo, TLM@CAP outperformed free metformin in restoring mitochondrial function, reducing cellular senescence, and rebalancing extracellular matrix metabolism via AMPK/mTOR pathway activation in senescent chondrocytes.”

   AnimalsOA modelintra-articular TLM@CAPcartilage

   A dual-engineered chondrocyte-targeting tetrahedral DNA-based nanoparticle for improved delivery of metformin and alleviation in osteoarthritis

   Biomaterials·6 Jul 2026

More on Cellular senescence