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Tideglusib

Intervention

1 paper1 finding

PubChemChEBI

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Institute of Diabetes and Digestive and Kidney Diseases and 2 more
  • Animals1

Outcomes

1

Podocyte injury

downin cells1

1 study

  1. Tideglusib decreases podocyte injury in cells.

    “These degenerative changes coincided with GSK3β hyperactivity, as evidenced by GSK3β overexpression and reduced inhibitory phosphorylation of GSK3β, and were averted by tideglusib”

    Cellsin cultured podocytes exposed to type 2 diabetes milieu

    The redox-sensitive GSK3β is a key regulator of glomerular podocyte injury in type 2 diabetic kidney disease

    Redox biology16 Mar 2024

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