Theanine
- 4 independent labs in 3 countries
- Funders: Japan Society for the Promotion of Science and 2 more
- Animals4
- Model organisms1
Outcomes
14Lifespan
upin mice1upin worms1
2 studies
Lifespan
upin mice1upin worms1
Theanine extends lifespan in worms.
“L-theanine, when administered during early adulthood, notably extended the lifespan of Caenorhabditis elegans under both normal and high-glucose-induced stress conditions.”
Model organisms
Foods (Basel, Switzerland)
Theanine extends lifespan in mice.
“consumption of purified theanine (20 μg/ml, 5-6 mg/kg) suppressed the shortened lifespan”
Animalsunder confrontational housing (psychosocial stress)purified20 μg/ml, 5-6 mg/kgmales
Free radical research
Stress
downin reviews1
1 study
Stress
downin reviews1
Theanine decreases stress.
“Theanine, a unique umami component of tea, has stress-reducing effects.”
Review
Effects of Japanese Green Tea on the Brain: Prevention of Aging
Brain and nerve = Shinkei kenkyu no shinpo
Advanced glycation end products
downin worms1
1 study
Advanced glycation end products
downin worms1
Theanine decreases advanced glycation end products in worms.
“L-theanine significantly diminishes the accumulation of advanced glycation end products (AGEs)”
Model organisms
Foods (Basel, Switzerland)
GABA/glutamic acid ratio
upin mice1
1 study
GABA/glutamic acid ratio
upin mice1
Theanine increases GABA/glutamic acid ratio in mice.
“GABA/glutamic acid and glutamine/glutamic acid ratios in the hippocampus showed an increasing tendency, a significant increase, and an increasing tendency with theanine administration”
Animalsin SAMP8 micehippocampus
Journal of nutritional science and vitaminology
CAMK2B
upin mice1
1 study
CAMK2B
upin mice1
Theanine increases CAMK2B in mice.
“expression of CAM kinase II beta and alpha exhibited a significant increase and increasing tendency with theanine administration”
Animalsin SAMP8 micehippocampus
Journal of nutritional science and vitaminology
SNCA
downin mice1
1 study
SNCA
downin mice1
Theanine decreases SNCA in mice.
“significant suppressions in the expressions of synapsin 2, α-synuclein, β-synuclein, and protein tau were observed by theanine administration”
Animalsin SAMP8 micehippocampus
Journal of nutritional science and vitaminology
Aging score
upin mice1
1 study
Aging score
upin mice1
Theanine improves aging score in mice.
“improvement in the aging score with theanine administration”
Animalsin SAMP8 micehippocampus
Journal of nutritional science and vitaminology
MAPK/ERK signaling
upin mice1
1 study
MAPK/ERK signaling
upin mice1
Theanine activates MAPK/ERK signaling in mice.
“theanine self-administration significantly attenuated inhibitions of JAK2/STAT3 phosphorylation, M1 mAChR expression, and ERK1/2 phosphorylation in the hippocampus of klotho mutant mice.”
Animalsin klotho mutant micehippocampus
Theanine attenuates memory impairments induced by klotho gene depletion in mice
Food & function
JAK–STAT signaling
upin mice1
1 study
JAK–STAT signaling
upin mice1
Theanine activates JAK–STAT signaling in mice.
“theanine self-administration significantly attenuated inhibitions of JAK2/STAT3 phosphorylation, M1 mAChR expression, and ERK1/2 phosphorylation in the hippocampus of klotho mutant mice.”
Animalsin klotho mutant micehippocampus
Theanine attenuates memory impairments induced by klotho gene depletion in mice
Food & function
Memory impairments
downin mice1
1 study
Memory impairments
downin mice1
Theanine decreases memory impairments in mice.
“Theanine significantly attenuated memory impairments in klotho mutant mice.”
Animalsin klotho mutant mice
Theanine attenuates memory impairments induced by klotho gene depletion in mice
Food & function