Tert-butylhydroquinone
- 2 independent labs in 2 countries
- Funders: Ellison Medical Foundation and 3 more
- Humans1
- Animals1
Outcomes
2Cellular senescence
downin human cells1
1 study
Cellular senescence
downin human cells1
Tert-butylhydroquinone decreases cellular senescence in human cells.
“pharmacological activation of NRF2 with tBHQ reversed MAFF-induced senescence, restored proliferative capacity, downregulated CDKN2A and CDKN1A”
Cellsin MAFF-overexpressing RDSCs
Journal of assisted reproduction and genetics28 Jul 2026
Phase I xenobiotic metabolizing enzyme genes
upin mice1
1 study
Phase I xenobiotic metabolizing enzyme genes
upin mice1
Tert-butylhydroquinone increases phase I xenobiotic metabolizing enzyme genes in mice.
“The same pattern of mRNA elevation could be induced by 2 wk of treatment with tert-butylhydroquinone”
Animals2 wk
American journal of physiology. Endocrinology and metabolism12 Jun 2012
Latest
1 in 12 monthsJournal of Assisted Reproduction and Genetics
MAFF promotes decidual stromal cell senescence by suppressing NRF2-mediated antioxidant responses in recurrent pregnancy loss
Case-control study in peopleNRF2–KEAP1 antioxidant response
Archives of Toxicology
Impact of nephrotoxins and oxidants on survival and transport function of hiPSC-derived renal proximal tubular cells
Experiments in cellsMechanisms
Stem Cells International
Transglutaminase 2 Prevents Premature Senescence and Promotes Osteoblastic Differentiation of Mesenchymal Stem Cells through NRF2 Activation
Experiments in cellsMechanisms
American Journal of Physiology Endocrinology and Metabolism
Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan
Experiments in miceInterventions