MAFF

1. MAFF increases oxidative stress and ROS signalling in human cells.

   “leading to reduced NQO1 expression and increased intracellular ROS levels.”

   Cellsin RDSCs

   MAFF promotes decidual stromal cell senescence by suppressing NRF2-mediated antioxidant responses in recurrent pregnancy loss

   Journal of assisted reproduction and genetics·28 Jul 2026

More on Oxidative stress and ROS signalling

1. MAFF decreases NQO1 in human cells.

   “MAFF physically interacted with NRF2, enhanced their nuclear co-localization, and competitively disrupted NRF2 binding to the ARE-F1 site within the NQO1 promoter, leading to reduced NQO1 expression”

   Cellsin RDSCs

   MAFF promotes decidual stromal cell senescence by suppressing NRF2-mediated antioxidant responses in recurrent pregnancy loss

   Journal of assisted reproduction and genetics·28 Jul 2026

More on NQO1

1. MAFF induces cellular senescence in human cells.

   “MAFF overexpression in RDSCs induced cellular senescence, characterized by increased SA-β-gal activity, increased CDKN2A and CDKN1A expression”

   Cellsin RDSCsMAFF-overexpressing lentivirus

   MAFF promotes decidual stromal cell senescence by suppressing NRF2-mediated antioxidant responses in recurrent pregnancy loss

   Journal of assisted reproduction and genetics·28 Jul 2026

More on Cellular senescence