Phase I xenobiotic metabolizing enzyme genes

1. Tert-butylhydroquinone increases phase I xenobiotic metabolizing enzyme genes in mice.

   “The same pattern of mRNA elevation could be induced by 2 wk of treatment with tert-butylhydroquinone”

   Animals2 wk

   Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan

   American journal of physiology. Endocrinology and metabolism·12 Jun 2012

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1. Rapamycin increases phase I xenobiotic metabolizing enzyme genes in mice.

   “many phase I XME genes are similarly upregulated in additional long-lived mouse models, including "crowded litter" (CL) mice, whose lifespan has been increased by food restriction limited to the first 3 wk of life, and in mice treated with rapamycin.”

   Animalsmice treated with rapamycin

   Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan

   American journal of physiology. Endocrinology and metabolism·12 Jun 2012

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1. Caloric restriction increases phase I xenobiotic metabolizing enzyme genes in mice.

   “Induction in the CL mice lasts at least through 22 mo of age”

   Animalscrowded litter micefirst 3 wk of life

   Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan

   American journal of physiology. Endocrinology and metabolism·12 Jun 2012

More on Caloric restriction