SRT1720
- 3 independent labs in 4 countries
- Funders: Helsingin ja Uudenmaan Sairaanhoitopiiri and 6 more
- 3 of 7 findings with company ties
- Animals3
Outcomes
6Cellular senescence
downin mice2
2 studies
Cellular senescence
downin mice2
SRT1720 decreases cellular senescence in mice.
“Activation of Sirt1 by SRT1720 neutralized the up-regulation of P53, P21, and P16 caused by Notch activation and eliminated Notch-driven LSEC senescence.”
Animalsin Cdh5-CreERT NICeCA mice with Notch activationliver
Hepatology (Baltimore, Md.)7 Dec 2021
SRT1720 decreases cellular senescence in mice.
“SIRT1 activation by both genetic overexpression and a selective pharmacological activator, SRT1720, attenuated stress-induced premature cellular senescence and protected against emphysema induced by cigarette smoke and elastase in mice.”
Animalsinduced by cigarette smoke and elastase
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice
The Journal of clinical investigation1 May 2012
Liver regeneration
upin mice1
1 study
Liver regeneration
upin mice1
SRT1720 improves liver regeneration in mice.
“Finally, Sirt1 activator promoted liver regeneration by abrogating LSEC senescence and improving sinusoid remodeling.”
Animalsafter partial hepatectomyliver
Hepatology (Baltimore, Md.)7 Dec 2021
Emphysema
downin mice1
1 study
Emphysema
downin mice1
SRT1720 protects against emphysema in mice.
“SIRT1 activation by both genetic overexpression and a selective pharmacological activator, SRT1720, attenuated stress-induced premature cellular senescence and protected against emphysema induced by cigarette smoke and elastase in mice.”
Animalsinduced by cigarette smoke and elastase
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice
The Journal of clinical investigation1 May 2012
Mitochondrion
no changein mice1
1 study
Mitochondrion
no changein mice1
SRT1720 has no effect on mitochondrion in mice.
“SRT1720 neither lowers plasma glucose nor improves mitochondrial capacity in mice fed a high fat diet.”
Animalsin mice fed a high fat diet
SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1
The Journal of biological chemistry8 Jan 2010
Glucose
no changein mice1
1 study
Glucose
no changein mice1
SRT1720 has no effect on glucose in mice.
“Furthermore, we demonstrate that SRT1720 neither lowers plasma glucose nor improves mitochondrial capacity in mice fed a high fat diet.”
Animalsin mice fed a high fat diet
SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1
The Journal of biological chemistry8 Jan 2010
SIRT1
no changein cells1
1 study
SIRT1
no changein cells1
SRT1720 has no effect on SIRT1 in cells.
“SRT1720, its structurally related compounds SRT2183 and SRT1460, and resveratrol do not lead to apparent activation of SIRT1 with native peptide or full-length protein substrates”
Cellswith native peptide or full-length protein substrates
SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1
The Journal of biological chemistry8 Jan 2010